Radnja filma prati Major (Scarlet Johansson) koja vodi elitnu jedinicu pod nazivom Sektor 9 zaduženu za najopasnije kriminalce. Njihov zadatak je da ih zaustaviti pa će morati da se suoči sa neprijateljem čijij je jedini cilj da uništi napredak tehnologije Hank Robotic’s-a.
In the near future, Major Motoko Kusanagi (Scarlett Johansson) is the first of her kind: A human saved from a terrible terrorist attack, who is cyber-enhanced to be a perfect soldier devoted to stopping the world's most dangerous criminals. When terrorism reaches a new level that includes the ability to hack into people's minds and control them, Major Kusanagi is uniquely qualified to stop it. As she prepares to face a new enemy, Major Kusanagi discovers that she has been lied to: her life was not saved, it was stolen. She will stop at nothing to recover her past, find out who did this to her and stop them before they do it to others.